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SciLifeLab, MAX IV and ESS tackle many questions at the atomic and molecular level!

Integrative structural biology course 2022

InfraLife course in integrative structural biology covered not only the basics of state-of-the-art structural biology techniques, but also how to combine the information to address a biological question. The course took place between Aug 22 and Sept 2nd 2022.

The two week course is a joint effort between the three large-scale research infrastructures SciLifeLab, MAX IV and ESS and additional related platforms. The aim is to give an overview of the structural biology available at the research infrastructures in Sweden. The course will focus on understanding the sample requirements, the nature of structural information that can be obtained and how data from multiple structural biology methods can be combined using e.g. computational chemistry techniques. The course consists of lectures, key note speakers, modelling practicals and facility visits. In addition events allowing time for networking within the group of students, the teachers and other infrastructure personnel, contributing to an expanded professional network.

  • *Macromolecular X-ray and neutron crystallography
  • *Small angle X-ray and neutron scattering 
  • *Cryo-electron microscopy
  • *Macromolecular nuclear magnetic resonance spectroscopy
  • *Structural mass spectrometry
  • *Modelling and Computational methods 
  • *Biophysical characterization

A number of exciting keynote speakers presented scientific examples of how integrative structural biology techniques can be used to solve intriguing questions.

  • Professor Poul Nissen, Aarhus University, Structure and mechanism of membrane transporters
  • Professor Carmen Domene, University of Bath, Computer simulations of complex biological systems
  • Research Specialist Hanna Barriga, Karolinska Institute, Coupling lipid nanoparticle structure and composition

We had several lectures on modelling and computational techniques for structural biology.

  • Associate professor Lucie Delemotte, Integrating physics-based and evolutionary modelling to investigate the conformational dynamics of membrane proteins
  • Professor Gunnar von Heijne, Different approaches to the study of cotranslational protein folding
  • Professor Erik Lindahl, Integrative structural biology: Combining cryo-EM, simulations and electrophysiology to understand membrane protein functions
  • Principal Research Engineer Claudio Mirabello, The protein structure prediction problem: from Anfinsen to AlphaFold.

The course was open to scientists of all age from academia, health care and industry. Level approximately corresponding to PhD student or postdoc depending on experience. Applicants welcome from Sweden, the Nordics, and other countries.



 

The organising group consists of:

OrganisationNameRole/Method
InfraLife projectJosefin Lundgren GawellCoordinator
InfraLife projectCat HalthurCoordinator
SciLifeLabDavid GottholdCoordinator
ESSEsko OksanenCrystallography
MAX IVSelma MaricSmall angle scattering
SciLifeLabCecilia PerssonNMR
SciLifeLabMarta CarroniCryo-EM
SciLifeLabMichael HallCryo-EM
SciLifeLabSimon EkströmStructural mass spectrometry
Lund UniversityLotta HapponenStructural mass spectrometry
SciLifeLabJessica LindvallCourse structure
Linköping University Maria SunnerhagenBiophysical characterisation
Linköping UniversityDean DerbyshireBiophysical characterisation

This InfraLife integrative structural biology course is organized with funding support from the Swedish research council, Lif, Excillum, NBIS, SwedNMR, Bruker, Thermo Fisher and CryoNET.

Thank you!